I got these last time and am pretty impressed. For the size and price, they really sound amazing.
I wouldn't recommend them for uses they weren't intended for, such as main speakers in a living room, but as desktop speakers, I can't imagine finding anything better in this price range. I've got a pair of M-Audio AV-40s at work, which definitely sound more "even" (flatter response), but they're more expensive, and not everybody actually likes flat sound (my coworkers think they sound boring). I've also used Klipsch ProMedia 2.1s, which probably beat the Audysseys in overall quality, but it kind of comes down to preference, and I don't happen to have room near my computer desk for a sub.
The Audysseys certainly aren't accurate the way a pair of studio monitors are, but they sound fine for entertainment. Bass response is pretty surprising, considering the size of the cabinets. If they were hidden out of view, and I was hearing them for the first time, I'd swear there was a sub hooked up (and I've heard many "budget" 2.1 systems that have much worse bass). Mids are recessed, and highs are a little sparkly, but that's just because I'm used to listening to monitor headphones.
As desktop speakers, they're fantastic, and I like the auto shutoff feature. I certainly wouldn't mind an auto-on function, but given the choice, I'd go with pressing a button to turn them on rather than needing to turn them on and off each time I use them. Of course, everyone's setup will be different, and if you don't have a desk where they sit right in front of you, you probably won't want to get up each time they shut off.
One thing to keep in mind: the optical input produces noticeably better sound than the analog input (this is almost universally true in non-hi-fi gear, so it shouldn't be a surprise). I was hoping to use an analog out from my DAC, but found it much better to use the optical out directly from my sound card. Luckily, I also have a coax digital out on my PC, so this wasn't an issue, but keep it in mind if you're running multiple audio devices.